Reproduktivna biologija in embriologija

Učni načrt

Podatki so iz učnega načrta, ki ga objavlja Medicinska fakulteta. Prebrano 6. 9. 2026. Poglej izvirnik

6 kreditnih točk

Obveznosti v urah

• Predavanja15 ur
• Vaje25 ur
• Samostojno delo130 ur
• Seminarji10 ur

Vsebina

1. Modo v fetusu, primordiale celice,
2. spermatogeneza, Leydigove in Sertolijeve celice, zorenje, morfologija / zgradba semenčic, funkcija posameznih struktur, semenski izliv.
3. Jajčnik v fetusu, primordialne celice, oogeneza, teka in granulozne celice, maturacija, folikulogeneza, morfologija in zgradba jajčne celice, delovanje posameznih struktur,
4. Združitev spolnih celic.
5. Embrionalni razvoj – med prvo delitvijo in implantacijo, poimplantacijska embriologija, nepravilnost razvoja zarodkov in vitro.
6. Laboratorijske tehnike oploditve z biomedicinsko pomočjo (OBMP): različna gojišča, osnovna analiza semena in priprave semena za postopke IUI, IVF in ICSI, z morfološko oceno semena in razširjeno analizo semena, biopsija testisa.
7. IVF in ICSI, fertilizacija, kultivacija zarodkov morfološke lastnosti, vitrifikacija, biopsija polarnega telesa, predimplantacijska genetska diagnostika.

Ocenjevanje

Pisni izpit 60 %, Laboratorijsko delo 20 %, Ustni izpit 20 %

Pogoji za vključitev

Kandidat mora doseči 300 ECTS na predhodnem študiju.

Literatura

• KOVAČIČ, Borut. Oploditev z biomedicinsko pomočjo - laboratorijski del. V: TAKAČ, Iztok (ur.), et al. Ginekologija in perinatologija. 1. izd. Maribor: Medicinska fakulteta. 2016, str. 196-205, ilustr. [COBISS.SI-ID 5670975]
• Dodatna literatura in viri / Additional reading materials:
• BREZNIK, Barbara, KOVAČIČ, Borut, VLAISAVLJEVIĆ, Veljko. The role and use of hyaluronan in reproductive medicine. V: POMIN, Vitor H. (ur.). Hyaluronan : biological and medical implications, (Biochemistry research trends). New York: Nova Science Publishers. cop. 2014, str. [113]-137, ilustr. [COBISS.SI-ID 5039167]
• KOVAČIČ, Borut, HOJNIK, Nina, VLAISAVLJEVIĆ, Veljko. The use of time lapse photography in an in vitro fertilization programme for better selection for embryo transfer. V: REYES, David (ur.), CASALES, Angelica (ur.). Embryo development : stages, mechanisms and clinical outcomes, (Human reproductive system - anatomy, roles and disorders). New York: Nova Science Publishers. cop. 2013, str. [113]-139, ilustr. [COBISS.SI-ID 4728895]
• KOVAČIČ, Borut, VLAISAVLJEVIĆ, Veljko. Importance of blastocyst morphology in selection for transfer. V: WU, Bin (ur.). Advances in embryo transfer. Rijeka: InTech. cop. 2012, str. [161]-176. http://www.intechopen.com/books/advances-in-embryo-transfer/importance-of-blastocyst-morphology-in-selection-for-transfer. [COBISS.SI-ID 4271167]
• VLAISAVLJEVIĆ, Veljko, KNEZ, Jure, KOVAČIČ, Borut. Does the number of retrieved oocytes influence pregnancy rate after day 3 and day 5 embryo transfer?. V: WU, Bin (ur.). Advances in embryo transfer. Rijeka: InTech. cop. 2012, str. [39]-52, ilustr. http://www.intechopen. com/books/advances-in-embryo-transfer/does-the-number-of-retrieved-oocytes-influence-pregnancy-rate-after-day-3-and-day-5-embryo-transfer-. [COBISS.SI-ID 4270911]
• VLAISAVLJEVIĆ, Veljko, KNEZ, Jure, KOVAČIČ, Borut. Does embryo transfer technique and personal experience influence pregnancy rate?. V: BERHARDT, Leon V. (ur.). Advances in medicine and biology, (Advances in medicine and biology, ISSN 2157-5398, vol. 39). New York: Nova Science. cop. 2012, str. [237]-252. [COBISS.SI-ID 4324671]
• VLAISAVLJEVIĆ, Veljko, DOŠEN, Marko, KOVAČIČ, Borut. Embryo quality and pregnancy outcome in infertile patients with endometriosis. V: CHAUDHURY, Koel (ur.), CHAKRAVARTY, Baidyanath (ur.). Endometriosis - basic concepts and current research trends. Rijeka: InTech. 2012, str. [383]-398. http://www.intechopen.com/books/endometriosis-basic-concepts-and-current-research-trends. [COBISS.SI-ID 4271935]
• KNEZ, Jure, KOVAČIČ, Borut, VLAISAVLJEVIĆ, Veljko. Effectiveness of Slovenian health insurance reimbursement policy in twin's rate reduction in medically assisted reproduction. V: DUPONT, Maison (ur.), RENAUD, Jean-Pierre (ur.). Siblings : social adjustments, interaction, and family dynamics, (Children's issues, laws and programs). New York: Nova Science Publisher's. cop. 2012, str. 125-140, ilustr. [COBISS.SI-ID 4454719]
• KRIŽANČIĆ BOMBEK, Lidija, KOVAČIČ, Borut, VLAISAVLJEVIĆ, Veljko. Morphology and aneuploidy of in vitro matured (IVM) human oocytes. V: STORCHOVA, Zuzana (ur.). Aneuploidy in health and disease. Rijeka: InTech. cop. 2012, str. [163]-192, ilustr.http://www.intechopen.com/books/aneuploidy-in-health-and-disease/aneuploidy-of-in-vitro-matured-ivm-human-oocytes. [COBISS.SI-ID4336447]
• KOVAČIČ, Borut. Culture systems : low-oxygen culture. V: SMITH, Gary D. (ur.), SWAIN, Jason E. (ur.), POOL, Thomas B. (ur.). Embryo culture : methods and protocols, (Methods in molecular biology, ISSN 1940-6029, 912). New York [etc.]: Humana Press. cop. 2012, str. 249-272. http://www.springerlink.com/content/t7470461p7m4718h/fulltext.pdf. [COBISS.SI-ID 4375615]
• KOVAČIČ, Borut, VLAISAVLJEVIĆ, Veljko. The use of pentoxifylline for triggering the movement of testicular sperm before their use in intracytoplasmic sperm injection in men with azoospermia. V: LEJEUNE, Thomas (ur.), DELVAUX, Pascal (ur.). Human spermatozoa : maturation, capacitation and abnormalities, (Human reproductive system - anatomy, roles, and disorders series). New York: Nova Science. cop. 2010, str. 355-378. [COBISS.SI-ID 3653951]
• KOVAČIČ, Borut. Cryopreservation - sperm TESE and MESA. V: RIZK, Botros (ur.), MONTAG, Markus (ur.). Standard operational procedures in reproductive medicine : laboratory and clinical practice, (Reproductive medicine and assisted reproductive techniques series). Boca Raton; London; New York: CRC Press. cop. 2017, str. 34-35. https://www.crcpress.com/Standard-Operational-Procedures-in-Reproductive-Medicine-Laboratory-and/Rizk-Montag/p/book/9781498719216. [COBISS.SI-ID 6096959]
• HOJNIK Nina, KOVAČIČ Borut Oocyte activation failure: Physiological and clinical aspects. V: SATO (ur.) Embryogenesis. Rijeka:InTech cop.2019 str 1-25.
• GIANAROLI Luca, FERRARETTI Anna Pia & KOVACIC Borut. Monitoring ART Safety and Biovigilance. V: KISSIN Dimitry M (ur.), ADAMSON David G (ur.), CHAMBERS Georgina (ur.), DE GEYTER Christian (ur.). Assisted Reproductive Technology Surveillance. ISBN 978-1-108-49858-6 . Cambridge. Cambridge University Press. 2019, str. 56-68.
• HREINSSON Julius, KOVAČIČ Borut. Regulation, Licensing, and Accreditation of the ART Laboratory in Europe. V: NAGY Zsolt Peter (ur.), VARGHESE Alex C. (ur.), AGARWAL Ashok (ur.). Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices Zurich : Springer Nature. 2019, str: 1-11.

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